Radiosensitization by the novel DNA intercalating agent vosaroxin
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چکیده
منابع مشابه
Radiosensitization by the novel DNA intercalating agent vosaroxin
PURPOSE Vosaroxin is a first in class naphthyridine analog structurally related to quinolone antibacterials, that intercalates DNA and inhibits topoisomerase II. Vosaroxin is not a P-glycoprotein receptor substrate and its activity is independent of p53, thus evading common drug resistance mechanisms. To evaluate vosaroxin as a clinically applicable radiation sensitizer, we investigated its eff...
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ژورنال
عنوان ژورنال: Radiation Oncology
سال: 2012
ISSN: 1748-717X
DOI: 10.1186/1748-717x-7-26